Not at all. I think most of those are easy shooters. The size of the gun (especially the S&W) takes away from the bite of the big bore. My .44 mag Super Blackhawk is one of my favorite shooters, and I'm not that big (5'10" 185#). I love the 4.5" .500 mag, but can't justify the cost of ammo. Getting a .45 ACP rechambered to .460 Rowland, and then shooting either load, seems the best idea and most affordable.