Been having a lot of issues with my wrists, especially the right one. So bad that Im needing to do all shifting with my left hand. Went to my LBS today to see what my options were beyond the current Shimano 105 group. The result is the Shimano Ultegra Di2 electronics. While it would typically be out of my price range the local Shimano rep is going to provide my LBS with a demo unit that was in the display case. It lowered the cost 35-40%
I purchased the optional climbing shifters. I suspect they will be my primary means of shifting.