I regularly deal with a guy who put a .357 in his mouth, flinched, and blew the front of his forehead off. Missing the front lobe of his brain didn't make him any less of an asshole.
I've never shot a person. Hopefully I never have to. Lord knows he's given me the opportunity, I just made different choices in those situations... that being said... I have shot the fuckk out of God's furry creatures. Bears, deer, pigs, rabbits, squirrels all found their way into my scope.
Squirrel shots are the best example of bullet wounds. I go on yearly squirrel hunts where we shoot 200-300 little buggers in a weekend. I've been going on that shoot for nearly 20 years. I've honestly shot thousands of them. You can't deny the results as you switch rifles. Hitting a squirrel with a 32gr .22lr HP at 1200 fps and hitting a squirrel with a 45gr .221 Fireball, or even a .223 varmint grenade, traveling near 3800 fps, makes a significantly different wound. Despite being a similar weight projectile, the former makes a small pop, often blasting guts all over. The later rips the little bodies into pieces, exploding parts in multiple directions. The waves of "hydrostatic shock" often vaporizes the squirrel into unidentifiable parts. I can tell you from experience, a .221 Fireball does more damage to a squirrel than a .308 155gr tactical round.