Take her shopping, big store with a big selection. She needs something she finds comfortable that she will shoot. I've had plenty of students blast a snubby revolver (someone told them to buy) that never shoot again.
Plenty of new firearms semi-auto pistols are fully ambidextrous. The FNH FNS series pistols come with or without manual safeties, duty size or compact, slide stops on both sides. The Ruger SR series are mostly ambidextrous (safeties and magazine releases), .22LR up to .45acp for whatever floats her boat. The Remington R51 had a rough start in 2014, so they stopped production. Getting very good reports on it now, to include a very easy to operate slide and low perceived recoil. Kahr makes good pistols, only the slide stop and trigger to worry about. Walter's CCP is getting good reports, with the mag release being reversable instead of truly ambi.
Again, let her try them out and see what fits her hand at the store. Then, if you have a range with rentals nearby, have her try a few. Few things suck worse than spending hundreds of dollars on something you hate.