Aside from reloading... since 99.9% of revolver CCW's don't carry reloads... aren't ALL revolvers "technically" ambidextrous?
I have a two shot .357 derringer that I do not carry spare ammo for. I do carry a second (or third) gun though, and at least one of them has reloads.
Honestly, why not a S&W 43C .22lr? Sure, it's a little bit pricier that others, but... It's a revolver, controllable, and has 8 rounds! She won't be upset with the performance, and will appreciate the cost and fun to practice. A .22lr at close range will FUK someones world up just fine, and multiply that FUK-Factor x8 and you have a complete scenario.