Easy-peasy bro! Basically you're going to be learning to put all your speeds/feeds, radii, sines/cosines, cutter paths into the control panel.
As with manual machining, there is always more than one way to skin a cat. Pay attention to tool paths...they can bite you in the azz. So long as you aren't maching clamps, jigs, or fixtures you're good.
And you will see scales of magnification of the old adage "The only thing I've ever seen two machinists agree upon is that a third machinist is doing it wrong."